It's no problem to have a different origin for your shipments than the return address that's printed on the label.

Just head to Settings > Ship From Address to edit or add a new ship from address, and uncheck the checkbox at the bottom:

A screenshot showing the 'Ship From Address' section of Settings. On the top half of the page in the 'Physical Address' section, there's an arrow pointing at the 'Address' field with a notation reading, 'Enter the full origin address, or the Post Office you drop off at.' Below the Physical Address section, it reads 'Use this address as the Return Address on my shipping labels,' with a checkbox to the left. There's an arrow pointing at this with a notation reading, 'Uncheck this.' Finally, in the section towards the bottom titled 'Return Address (optional),' an arrow points at the address field with a notation reading 'Enter your address.'

The Physical Address is the "Origin," and is where the postage rates are calculated from. You have to enter a full address for the Physical Address of where your shipments will originate, not just the zipcode. 

For example, you could enter the address of the Post Office you'll be dropping off at (use the USPS Post Office Locator to find the address).

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